Atypia / premalignant / preinvasive lesions
Reviewer: Marilin Rosa, M.D., University of Florida (see Reviewers page)
Revised: 8 June 2011, last major update June 2011
Copyright: (c) 2006-2011, PathologyOutlines.com, Inc.
● Severe changes less than carcinoma
● Clinical history is important
● Usually low cellularity
● Multinucleated giant cells, large atypical cells with marked cytoplasmic vacuoles
● Intermediate parabasal cells have nuclear enlargement 2.5 to 3.0x normal, but with low N/C ratio due to increased cytoplasm
● Chromatin is smudgy or finely granular
● Prominent nucleoli
● Smear also shows endothelial cells and macrophages (Diagn Cytopathol 1995;13:107), but clean background
End of Cervix-cytology > Atypia / premalignant / preinvasive lesions > Radiation atypia
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