Cervix - Cytology
Benign cells / nonneoplastic lesions

Author: Farnaz Hasteh, M.D. (see Authors page)

Revised: 16 May 2017, last major update June 2011

Copyright: (c) 2006-2017, PathologyOutlines.com, Inc.

PubMed search: cervix repair [title]

Cite this page: Repair. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cervixcytologyrepair.html. Accessed October 17th, 2018.
Definition / general
  • When mucosa is denuded or damaged, the underlying or peripheral epithelial cells rapidly proliferate with increased protein synthesis to fill the defect; these cells have cytologic features described below, which may mimic malignancy
Clinical features
  • Differentiating repair from dysplasia is very important
Cytology description
  • Cohesive monolayers of cells with well defined or indistinct borders, abundant cytoplasm (usually blue but no organgophilia / keratinization), uniform enlarged nuclei, finely granular and evenly distributed chromatin; nuclei may be hypo to hyperchromatic but almost all have prominent round nucleoli and normal N/C ratio
  • Cells still keep their order and do not overlap although they may fold on themselves, giving the impression of a syncytium
  • Almost all cases have a chronic inflammatory infiltrate
  • May see multi nucleation
  • Normal mitotic figures may be seen
  • Single cells are rare
  • If atypia present, must include diagnosis of ASCUS in cytology report, although this has been questioned (Diagn Cytopathol 2005;33:214)
  • In liquid based cytology, repair groups are more rounded because of preparation
Cytology images

Images hosted on other servers:
Missing Image

Reparative changes - various images

HSIL not repair

Positive stains
Negative stains
Differential diagnosis