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Serous papillary adenocarcinoma

Reviewer: Nat Pernick, M.D., PathologyOutlines.com, Inc. (see Reviewers page)
Revised: 26 June 2011, last major update June 2011
Copyright: (c) 2006-2011, PathologyOutlines.com, Inc.

Cytology description

● Hypercellar smears with tumor diathesis, papillae, bulky dense cytoplasm, bare nuclei and cells with large pleomorphic nuclei (Cancer 1997;81:98) and numerous nucleoli (Cytopathology 2005;16:125)
● Also monolayered sheets of mildly atypical glandular cells with papillary branches
● Also pseudopapillary fragments, tight balls of cells resembling endometrial glandular cells, squamoid cells
● Marked tumor diathesis with primary disease but not metastatic disease to cervix
● Also psammoma bodies

Cytology images

Cervical tumor: H&E, peritoneal fluid

Uterine tumor: peritoneal fluid

Differential diagnosis

Endometrioid carcinoma: Monomorphic cells with delicate cytoplasm and moderately enlarged oval nuclei

End of Cervix-cytology > Carcinoma > Serous papillary adenocarcinoma

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