Cervix - Cytology
Benign cells / nonneoplastic lesions
Small blue cells

Topic Completed: 1 March 2011

Revised: 21 December 2018, last major update March 2011

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PubMed search: small blue cells cervix

Farnaz Hasteh, M.D.
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Cite this page: Hasteh F. Small blue cells. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cervixcytologysmallbluecell.html. Accessed January 25th, 2020.
Definition / general
  • Associated with tamoxifen therapy (present in 40% of Pap smears of patients with tamoxifen therapy) and atrophy
  • Not associated with malignancy
  • May represent reserve cells of cervical / vaginal epithelium (Arch Pathol Lab Med 2001; 125:1047)
Microscopic (histologic) description
  • Tight clusters of undifferentiated small cells with minimal cytoplasm or naked nuclei, round to oval nuclei, bland chromatin, indistinct nucleoli
Cytology images

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Dark, tightly cohesive clusters

Differential diagnosis
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