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Villoglandular papillary adenocarcinoma

Reviewer: Nat Pernick, M.D., PathologyOutlines.com, Inc. (see Reviewers page)
Revised: 26 June 2011, last major update June 2011
Copyright: (c) 2006-2011, PathologyOutlines.com, Inc.


● Infrequent, well differentiated tumor of young women; genereal considered to have a good prognosis due to lack of lymphovascular invasion (Eur J Gynaecol Oncol 2009;30:211)
● Diagnosis often missed due to bland cytologic features (Malays J Pathol 2003;25:139)

Cytology description

● Large cohesive groups of endocervical cells with nuclear crowding and loss of normal honeycomb pattern
● Has true papillary structures with long, slender papillae containing stromal cores covered by well polarized columnar cells with intact cytoplasmic borders but no feathered edge
● Mildly atypical cells with crowding and overlapping of nuclei; nuclei are uniform, small, round/oval with evenly distributed granular chromatin; no/inconspicuous nucleoli
● Occasional mitotic figures and apoptotic bodies

Molecular description

● HPV 16 (Mod Pathol 2005;18:528)

End of Cervix-cytology > Carcinoma > Villoglandular papillary adenocarcinoma

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