Cervix
Benign / nonneoplastic epithelial lesions
Diffuse laminar endocervical hyperplasia
Author: Branko Perunovic, D.M.
Last author update: 1 May 2007
Last staff update: 13 December 2022
Copyright: 2007-2024, PathologyOutlines.com, Inc.
PubMed Search: Diffuse laminar endocervical glandular hyperplasia cervix
Table of Contents
Definition / general | Case reports | Microscopic (histologic) description | Negative stains | Differential diagnosisCite this page: Perunovic B. Diffuse laminar endocervical hyperplasia. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cervixdiffuselaminar.html. Accessed April 20th, 2024.
Definition / general
- Also called nonspecific hyperplasia
- Usually an incidental finding
- First described in 1991 (Am J Surg Pathol 1991;15:1123)
- Mean age 37 years, range 22 to 48 years
- Nonneoplastic, incidental finding, no recurrences after surgery
Case reports
- 54 year old woman with 7 year history of watery vaginal discharge (Pathol Int 1995;45:283)
Microscopic (histologic) description
- Diffuse proliferation of medium sized, evenly spaced, closely packed, well differentiated mucinous glands within inner third of cervical wall
- Area sharply demarcated from underlying storm
- Cells have basal nuclei
- Associated with chronic inflammation and stromal edema
- No significant cytologic atypic
- No mitotic activity, no / rare apoptotic activity (Int J Gynecol Pathol 2002;21:125), not deeply invasive
Negative stains
Differential diagnosis
- Minimal deviation adenocarcinoma: irregular stromal infiltration, deeply invasive with desmoplastic stroma, cytologic atypia, not an incidental finding
