Reviewer: Jaya Ruth Asirvatham M.B.B.S., M.D. (see Reviewers page)
Editor: Sharon Liang, M.D., Ph.D.
Revised: 20 June 2013, last major update May 2013
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
- Develops from mesoderm-derived Müllerian (paramesonephric) ducts
- Cranial end of Müllerian ducts become future fallopian tubes; caudal ends fuse in midline to form Y shaped canal (uterovaginal primordium)
- Uterovaginal primordium meets endoderm derived urogenital sinus at Müllerian tubercle (location of vaginal orifice at hymenal ring)
- Uterovaginal primordium gives rise to fibromuscular wall of vagina, epithelium and glands of corpus uteri and cervix; endometrium and stroma develop from adjacent mesenchyme
- Epithelium of vagina is largely derived from urogenital sinus by upgrowth of sinovaginal bulbs that fuse to form vaginal plate, which subsequently breaks down centrally, leaving periphery as vaginal epithelium
- Acien classification: Hum Reprod Update 2011;17:693
- DES exposed female fetus is at risk for congenital malformation of cervix and vagina
Fusion of Müllerian ducts
Classic theory vs Acien theory
Congenital anomalies of uterus and cervix
Congenital uterine malformations
End of Cervix > General > Embryology
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