Author: Jaya Ruth Asirvatham M.B.B.S., M.D.(see Authors page)
Editor: Sharon Liang, M.D., Ph.D.

Revised: 1 March 2017, last major update June 2013

Copyright: (c) 2003-2017, PathologyOutlines.com, Inc.

PubMed Search: Cervix[title]Embryology
Cite this page: Embryology. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cervixembryology.html. Accessed October 17th, 2018.
Definition / general
  • Develops from mesoderm-derived Müllerian (paramesonephric) ducts
  • Cranial end of Müllerian ducts become future fallopian tubes; caudal ends fuse in midline to form Y shaped canal (uterovaginal primordium)
  • Uterovaginal primordium meets endoderm derived urogenital sinus at Müllerian tubercle (location of vaginal orifice at hymenal ring)
  • Uterovaginal primordium gives rise to fibromuscular wall of vagina, epithelium and glands of corpus uteri and cervix; endometrium and stroma develop from adjacent mesenchyme
  • Epithelium of vagina is largely derived from urogenital sinus by upgrowth of sinovaginal bulbs that fuse to form vaginal plate, which subsequently breaks down centrally, leaving periphery as vaginal epithelium
  • Acien classification: Hum Reprod Update 2011;17:693
  • DES exposed female fetus is at risk for congenital malformation of cervix and vagina
Diagrams / tables

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Fusion of Müllerian ducts

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Classic theory vs Acien theory

Congenital anomalies of uterus and cervix
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Congenital uterine malformations