Premalignant / preinvasive lesions - H&E
Endocervical glandular atypia / dysplasia

Topic Completed: 1 May 2007

Minor changes: 9 March 2020

Copyright: 2007-2020, PathologyOutlines.com, Inc.

PubMed search: Endocervical glandular atypia cervix

Branko Perunovic, D.M.
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Cite this page: Perunovic B. Endocervical glandular atypia / dysplasia. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cervixendocervglandatypia.html. Accessed August 7th, 2020.
Definition / general
  • More severe cases are called endocervical glandular dysplasia (atypical hyperplasia)
  • In United Kingdom, use terminology of CGIN - cervical glandular intraepithelial neoplasia
  • Not a reproducibly defined entity with a specific cause or outcome
  • Patients with diagnosis based on cervicovaginal smears often have squamous dysplasia (Obstet Gynecol 1992;79:101)
  • Appears to NOT be a precursor to adenocarcinoma in situ (Hum Pathol 2000;31:656)
  • Atypical oxyphilic metaplasia: incidental finding of endocervical glands lined by large cuboidal or polygonal epithelial cells with dense, eosinophilic, focally vacuolated cytoplasm and variable nuclear enlargement, hyperchromatism, multiple lobes or multinucleation; no mitotic activity or stratification; benign behavior (Int J Gynecol Pathol 1997;16:99)
Microscopic (histologic) description
Glandular atypia
  • Glandular cells with hyperchromatic nuclei with only occasional mitotic figures and minimal pseudostratification
  • No cribriform areas, no papillary projections, no crowding, no mitotic figures
  • Alternatively there is marked atypia involving only a single gland
  • Normal N/C ratio
Glandular dysplasia
  • Resembles adenocarcinoma in situ but nuclei are not malignant and have fewer mitotic figures OR malignant involvement of only one gland
Microscopic (histologic) images

Images hosted on PathOut server:

Reactive glandular atypia

Glandular dysplasia

Cytology description
Positive stains
Negative stains
  • HPV (usually)
Differential diagnosis
Additional references
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