Sarcoma / lymphoma / other
Ewing sarcoma / PNET

Topic Completed: 1 May 2007

Revised: 26 December 2019

Revised: 28 December 2018, last major update May 2007

Copyright: (c) 2007-2017, PathologyOutlines.com, Inc.

PubMed Search: Ewing sarcoma PNET cervix

Branko Perunovic D.M.
Page views in 2019: 395
Page views in 2020 to date: 24
Cite this page: Perunovic B. Ewing sarcoma / PNET. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cervixewing.html. Accessed January 17th, 2020.
Definition / general
  • Extremely rare, < 20 cases reported
  • May present as abnormal uterine bleeding
  • May have similar prognostic factors as other sites (5 year survival of 70% with chemotherapy), although limited number of cases
Case reports
  • Surgery and chemotherapy
Gross description
  • May be necrotic and hemorrhagic
Microscopic (histologic) description
  • Diffuse sheets of small round cells with scant cytoplasm, hyperchromatic and vesicular nuclei, indistinct nucleoli
Positive stains
Molecular / cytogenetics description
  • t(11:22)(q24,q12) - EWS/FLI1 fusion transcript
Electron microscopy description
  • Large glycogen pools in cytoplasm, few cytoplasmic organelles, rare neurosecretory granules, no cell projections
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