Inflammation / parasites

Topic Completed: 1 November 2010

Revised: 21 December 2018, last major update November 2010

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PubMed search: Cervix granuloma

Farnaz Hasteh, M.D.
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Cite this page: Hasteh F. Granulomas. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cervixgranulomas.html. Accessed January 25th, 2020.
Definition / general
  • Chronic inflammation with epithelioid histiocytes, giant cells and lymphocytes
  • Rare
  • Usually foreign body type; also diffuse
  • Associated with prior biopsy or surgery (Am J Clin Pathol 2002;117:771)
  • Only rarely associated with sarcoidosis or systemic conditions
  • Ceroid (with early lipofuscin) granulomas may be related to endometriosis (J Clin Pathol 1995;48:1057)
  • Also called granulomatous cervicititis
  • Uncommon
  • Tuberculosis, amebiasis, schistosomiasis, brucellosis, tularemia, sarcoidosis and noninfectious causes like foreign body reaction to sutures (Diagn Cytopathol 1995;13:336)
  • Also post radiation
Case reports
Microscopic (histologic) description
  • Collection of epithelioid histiocytes or granuloma
Microscopic (histologic) images

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Xanthogranuloma (ceroid granuloma)

B: Perls' iron stain+
C: Ziehl-Neelsen (acid fast)+
D: Schmorl's reagent (melanin)+

Cytology description
  • Inflammatory reaction, foreign body giant cells, phagocytosed refractile suture material (in some cases)
  • Granuloma rarely seen in Pap test (tuberuclosis)
Differential diagnosis
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