Herpes simplex virus (HSV)

Author: Dr. Branko Perunovic, M.D. (see Authors page)

Revised: 5 May 2017, last major update May 2007

Copyright: (c) 2006-2017, PathologyOutlines.com, Inc.

PubMed Search: Herpes simplex virus cervix

Cite this page: Inflammation - Herpes simplex virus (HSV). PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cervixhsv.html. Accessed September 26th, 2017.
Definition / general
  • Relatively common; 3% (HSV1) and 8% (HSV2) of women visiting US physicians in one study (J Clin Virol 2005;33:25)
  • Neonatal herpes may occur if infant is delivered vaginally during maternal genital herpes
Microscopic (histologic) description
  • Epithelial ulcers with acute and chronic inflammatory cells, epithelial cell necrosis
  • Multinucleate cells with intranuclear inclusions that are smudged (ground glass) or discrete are usually at periphery of ulcer
  • Usually affects squamous cells not endocervical glandular epithelium
Cytology description
Electron microscopy description
  • Ground glass appearance is due to intranuclear viral particles
  • Enhancement of nuclear envelope is caused by peripheral chromatin margination
Differential diagnosis
  • Inflammatory cells with multiple nuclei: lack discrete nuclear molding