Cervix
Benign / nonneoplastic lesions
Mesonephric hyperplasia

Author: Carlos Parra-Herran, M.D. (see Authors page)

Revised: 22 August 2018, last major update April 2017

Copyright: (c) 2007-2018, PathologyOutlines.com, Inc.

PubMed Search: Mesonephric hyperplasia cervix

Cite this page: Parra-Herran, C. Mesonephric hyperplasia. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cervixmesonephrichyper.html. Accessed October 19th, 2018.
Definition / general
Microscopic (histologic) description
  • Mesonephric duct remnants appear as groups of round glands and tubules, lined by simple flat to low cuboidal epithelium
  • Glandular lumen is usually filled with a dense eosinophilic PAS positive, diastase resistant material; mucinous or ciliated cells are not identified
  • Hyperplasia of mesonephric ducts is characterized by a glandular population similar to mesonephric remnants but larger, more irregular and haphazardly distributed with increase in lobule size and extensive involvement of the cervix
  • Either lobular, diffuse (bland glands, no stromal reaction) or ductal patterns (large, dilated or irregular ducts in wall of cervix with micropapillary budding of pseudostratified epithelial cells without atypia); lobular is the most frequent
  • Small round mesonephric tubules are often deep within cervical wall and extend to cervical surface
  • May appear infiltrative
  • No back to back glandular crowding, no nuclear atypia, no angiolymphatic invasion, no perineural invasion
Microscopic (histologic) images

Images hosted on PathOut server:

AFIP images:

Marked tubular
proliferation but with
lobular architecture

More nuclear
variation than in
mesonephric rests

Bland glands deep in cervical stroma


Contributed by Carlos Parra-Herran, M.D.
Cytology description
Positive stains
Negative stains
Differential diagnosis
Additional references