Benign / nonneoplastic lesions
Mesonephric hyperplasia

Topic Completed: 1 April 2017

Revised: 27 December 2018, last major update April 2017

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PubMed Search: Mesonephric hyperplasia cervix

Carlos Parra-Herran, M.D.
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Cite this page: Parra-Herran C. Mesonephric hyperplasia. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cervixmesonephrichyper.html. Accessed January 26th, 2020.
Definition / general
Microscopic (histologic) description
  • Mesonephric duct remnants appear as groups of round glands and tubules, lined by simple flat to low cuboidal epithelium
  • Glandular lumen is usually filled with a dense eosinophilic PAS positive, diastase resistant material; mucinous or ciliated cells are not identified
  • Hyperplasia of mesonephric ducts is characterized by a glandular population similar to mesonephric remnants but larger, more irregular and haphazardly distributed with increase in lobule size and extensive involvement of the cervix
  • Either lobular, diffuse (bland glands, no stromal reaction) or ductal patterns (large, dilated or irregular ducts in wall of cervix with micropapillary budding of pseudostratified epithelial cells without atypia); lobular is the most frequent
  • Small round mesonephric tubules are often deep within cervical wall and extend to cervical surface
  • May appear infiltrative
  • No back to back glandular crowding, no nuclear atypia, no angiolymphatic invasion, no perineural invasion
Microscopic (histologic) images

Images hosted on PathOut server:

AFIP images:

Marked tubular
proliferation but with
lobular architecture

More nuclear
variation than in
mesonephric rests

Bland glands deep in cervical stroma

Contributed by Carlos Parra-Herran, M.D.
Cytology description
Positive stains
Negative stains
Differential diagnosis
Additional references
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