Benign / nonneoplastic lesions
Mesonephric rests / remnants

Author: Branko Perunovic, M.D. (see Authors page)

Revised: 26 October 2017, last major update May 2007

Copyright: (c) 2007-2017, PathologyOutlines.com, Inc.

PubMed Search: Mesonephric rests

Cite this page: Mesonephric rests / remnants. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cervixmesonephricrest.html. Accessed October 15th, 2018.
Definition / general
  • Remnants of mesonephric (Wolffian) ducts which form the epididymis and vas deferens in males, present in 1/3 of women
  • Unrelated to symptoms that cause excision of tissue; usually no clinical mass (Am J Surg Pathol 1990;14:1100)
  • Mesonephric adenocarcinoma is a rare varient of cervical adenocarcinoma that arises from mesonephric rests deep in the cervical stroma
Case reports
Microscopic (histologic) description
  • Dilated tubules of cuboidal cells with eosinophilic secretions, surrounded by endocervical stroma
  • May undergo atypical hyperplastic changes or malignant change
Microscopic (histologic) images

Images hosted on PathOut server:

Clusters of mesonephric
tubules surround a
branching duct

Mesonephric remnants with hyaline secretion

Cells are cuboidal
with a distinct basement

Complex and deep
duct with focal
squamous metaplasia

Images hosted on other servers:


Cytology description
Negative stains
Differential diagnosis
  • Adenocarcinoma: involves overlying endocervical mucosa, invasive, has stromal response and cytologic atypia, no lobular pattern, no intraluminal eosinophilic material
Additional references