Topic Completed: 1 April 2017

Revised: 20 December 2018, last major update April 2017

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PubMed Search: metaplasia [title] AND cervix [title]

Related topics: Atypical oxyphilic, Epidermoid, Immature squamous, Intestinal, Squamous, Tuboendometrioid, Urothelial

Jaya Ruth Asirvatham, M.B.B.S.
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Cite this page: Asirvatham J. Metaplasia. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cervixmetaplasia.html. Accessed October 21st, 2019.
Definition / general
  • Metaplasia is a nonneoplastic transformation of one mature cell type to another mature cell type that is not normally present at that location
  • The most common is squamous metaplasia of endocervical epithelium (mature and immature)
  • Pyloric, intestinal, transitional cell, tuboendometrioid, oxyphil, sebaceous, ectodermal appendage, cartilaginous and osseous metaplasia have been reported
  • Derived from the Greek words meta (after) and plasma (something formed)
  • Squamocolumnar junction, decubitus ulcer in prolapse, etc.
  • Subcolumnar reserve cells of the endocervical epithelium proliferate, stratify, differentiate and mature into squamous (or ciliated columnar) cells
  • Recently embryonic cells have been discovered at the squamo-columnar junction and a "top-down" pattern of differentiation has recently been described
  • In this model the reserve cells are the progeny of the embryonic cells with different susceptibilities to infection by HPV and implications for neoplastic evolution
  • Trauma, chronic irritation or cervical infection can stimulate repair and metaplasia or the cause can be iatrogenic (cryosurgery etc.)
Case reports
Endocervical bone metaplasia:
Ectodermal appendages:
Pyloric metaplasia:
  • 53 year old woman with lobular endocervical glandular hyperplasia and possible relationship between chronic inflammation and pyloric metaplasia (Eur J Gynaecol Oncol 2009;30:707)
Microscopic (histologic) images

Images hosted on other servers:

Osseous and cartilaginous metaplasia

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