Cervix
Metaplasia
Metaplasia


Topic Completed: 1 April 2017

Minor changes: 23 May 2020

Copyright: 2003-2020, PathologyOutlines.com, Inc.

PubMed Search: metaplasia [title] AND cervix [title]

Related topics: Immature squamous, Squamous, Tuboendometrioid

Jaya Ruth Asirvatham, M.B.B.S.
Page views in 2019: 2,742
Page views in 2020 to date: 1,671
Cite this page: Asirvatham JR. Metaplasia. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cervixmetaplasia.html. Accessed July 8th, 2020.
Definition / general
  • Metaplasia is a nonneoplastic transformation of one mature cell type to another mature cell type that is not normally present at that location
  • The most common is squamous metaplasia of endocervical epithelium (mature and immature)
  • Pyloric, intestinal, transitional cell, tuboendometrioid, oxyphil, sebaceous, ectodermal appendage, cartilaginous and osseous metaplasia have been reported
  • Epidermoid metaplasia is very rare; associated with uterine prolapse, prolonged irritation or synthetic steroids (Obstet Gynecol 1974;44:53); histology shows epidermis, sebaceous glands and hair follicles (J Low Genit Tract Dis 2008;12:217)
Terminology
  • Derived from the Greek words meta (after) and plasma (something formed)
Sites
  • Squamocolumnar junction, decubitus ulcer in prolapse, etc.
Pathophysiology
  • Subcolumnar reserve cells of the endocervical epithelium proliferate, stratify, differentiate and mature into squamous (or ciliated columnar) cells
  • Recently embryonic cells have been discovered at the squamo-columnar junction and a "top-down" pattern of differentiation has recently been described
  • In this model the reserve cells are the progeny of the embryonic cells with different susceptibilities to infection by HPV and implications for neoplastic evolution
Etiology
  • Trauma, chronic irritation or cervical infection can stimulate repair and metaplasia or the cause can be iatrogenic (cryosurgery etc.)
Case reports
Microscopic (histologic) images

AFIP images

With sebaceous glands

Back to top