Cytologic features
Squamous metaplasia

Topic Completed: 1 April 2017

Minor changes: 23 May 2020

Copyright: 2003-2020, PathologyOutlines.com, Inc.

PubMed Search: Squamous metaplasia[title]

Jaya Ruth Asirvatham, M.B.B.S.
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Cite this page: Asirvatham JR. Squamous metaplasia. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cervixmetaplasiasquamous.html. Accessed July 13th, 2020.
Definition / general
  • Replacement of endocervical epithelium by subcolumnar reserve cells, which differentiate into immature and then mature squamous epithelium
  • Common response to chronic irritation in nonsquamous tissue
  • Present in almost every cervix
  • Centered on transformation zone
  • May also arise from ingrowth of squamous epithelium from ectocervix (squamous epithelialization)
  • Not a premalignant condition by itself
  • Keratosis: appearance of granular and horny epithelial layers, often associated with prolapsed uteri
Case reports
Microscopic (histologic) description
  • Squamous epithelium overlies endocervical glands, may replace glands
  • Metaplastic cells may be immature, intermediate or mature
  • Resembles epithelium normally lining ectocervix with flat architecture
  • May have cytologic atypia
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