Tuboendometrioid metaplasia

Topic Completed: 1 April 2017

Revised: 14 December 2019

Copyright: 2002-2019, PathologyOutlines.com, Inc.

PubMed Search: Tubo endometrioid metaplasia

Jaya Ruth Asirvatham, M.B.B.S.
Anjelica Hodgson, M.D.
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Cite this page: Tuboendometrioid metaplasia. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cervixmetaplasiatuboendometrial.html. Accessed January 27th, 2020.
Definition / general
  • Common (1/3 of women)
  • In upper portion of endocervical canal, often in deep glands (Int J Gynecol Pathol 1992;11:89)
  • Often seen after cervical cone biopsy
  • May represent response to injury
  • Tubal epithelium is invariably seen at the cervix - isthmus junction and is not considered a metaplastic process at that site (Int J Gynecol Pathol 2013;32:122)
Microscopic (histologic) description
  • Endocervix contains:
    • Ciliated cells (clear cytoplasm, abundant apical cilia and large, oval, variably hyperchromatic nuclei)
    • Secretory cells (nonciliated with dark eosinophilic or basophilic cytoplasm, apical cytoplasmic protrusions but no mucin vacuoles, basal nuclei)
    • Intercalated cells (also called peg cells, scant cytoplasm, thin and long nuclei), as found in normal fallopian tube
  • Glands are regular
  • Minimal mitotic activity, rare crowding or atypia
  • Associated with endometrial type cells
  • Usually near squamocolumnar junction, usually no inflammation
  • May have cystic glands and periglandular stromal alterations suggestive of premalignant conditions or deep glands with periglandular edema suggestive of well differentiated adenocarcinoma but cells are ciliated with bland cytology, no mitotic figures, no definite desmoplastic stroma (Am J Clin Pathol 1995;103:618)
Microscopic (histologic) images

Images hosted on PathOut server:

Images contributed by Dr. Carlos Parra-Herran:

TEM and relevant stains

Images hosted on other servers:
Missing Image

Tubal metaplasia; far right is BCL2 staining

Positive stains
Negative staining - disease
  • p16 is considered to be negative or only focally positive or show a mosaic pattern in tubal metaplasia (Adv Anat Pathol 2006;13:8, Cell Oncol 2007;29:37), useful to differentiate from high grade CIN and invasive cervical carcinomas that are diffusely positive
Cytology description
Differential diagnosis
Additional references
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