Topic Completed: 1 May 2007

Minor changes: 10 March 2020

Copyright: 2007-2020, PathologyOutlines.com, Inc.

PubMed Search: "metastatic to" cervix

Branko Perunovic, D.M.
Marilin Rosa, M.D.
Page views in 2019: 513
Page views in 2020 to date: 173
Cite this page: Perunovic B, Rosa M. Metastases. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cervixmets.html. Accessed May 29th, 2020.
Definition / general
  • Extragenital tumors more commonly metastasize to ovary and vagina than cervix
  • Usually from ovary, breast, colon (Arch Pathol Lab Med 2003;127:1586), stomach, kidney; evidence of widespread disease is usually present
  • Direct extension from endometrial primary tumor is also common (particularly poorly differentiated adenocarcinoma)
  • Often involves cervical stroma and NOT surface epithelium or endocervical glands
  • Rarely due to metastatic mucinous carcinoma of appendix
Case reports
Microscopic (histologic) description
  • Usually no in situ component
  • Extensive angiolymphatic invasion is present, even in small and superficial lesions
Microscopic (histologic) images


Breast carcinoma metastatic to cervix

Case of week #125 (metastatic lobular carcinoma to endometrial polyp):

Various images




Cytology description
  • Yield for positive Pap smear diagnoses in extrauterine malignancies is best in patients with an established diagnosis (Acta Cytol 1999;43:806)
Cytology images

Contributed by Carmen Luz, M.D.
Missing Image

Ovarian clear cell carcinoma

  • Immunohistochemistry panels will vary according to site of origin
  • Clinical history important when selecting panels of immunostains
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