Microinvasive adenocarcinoma

Topic Completed: 1 March 2016

Revised: 24 September 2019

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed Search: Microinvasive adenocarcinoma [title] cervix

Ashwyna Sunassee, M.D.
Ryan W. Askeland, M.D.
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Cite this page: Sunassee A. Microinvasive adenocarcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cervixmicroinvasiveadeno.html. Accessed November 13th, 2019.
Definition / general
Essential features
  • ~12% of all microinvasive cervical carcinoma (Int J Gynecol Pathol 2000;19:29)
  • An increased number of microcarcinomas are diagnosed in young women in childbearing age, which coincides with the most common period for the onset of preneoplastic cervical lesions (Cancer 2010;116:2343)
Clinical features
  • Often asymptomatic (atypical glandular cells on Pap test)
Prognostic factors
  • Endocervical "usual type" associated with better prognosis
  • Endometrioid or clear cell histology may be associated with late recurrence and worse survival in stage 1A1 and 1A2 MIAC. (Gynecol Oncol 2011;121:135)
Case reports
Microscopic (histologic) description
  • Endocervical "usual type": most common histology, arising close to squamous-columnar junction in more than 90% of cases
  • Endometrioid and clear cell types may arise in any place along the cervical canal (Gynecol Oncol 2011;121:135)
  • Up to 5 mm of invasive disease as measured from surface
  • Budding of cells from adenocarcinoma in situ gland
  • Vesicular nuclei with prominent nucleoli
  • Desmoplastic stroma
  • Glands deeper than normal endocervical glands or invasive growth pattern
  • Pathologic staging:
    • pT1a1: Stromal invasion ≤3.0 mm in depth and horizontal spread ≤7.0 mm
    • pT1a2: Stromal invasion >3.0 mm but not more than 5.0 mm in depth and horizontal spread ≤7.0 mm
Microscopic (histologic) images

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Various images

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Abrupt transition

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Goblet cell metaplasia

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Crowded glands

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Buds of early stromal invasion

Cytology description
Positive stains
Additional references
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