Benign / nonneoplastic lesions

Topic Completed: 1 May 2007

Revised: 27 December 2018, last major update May 2007

Copyright: (c) 2007-2017, PathologyOutlines.com, Inc.

PubMed Search: Myofibroblastoma cervix[title}

Branko Perunovic D.M.
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Cite this page: Perunovic B. Myofibroblastoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cervixmyofibroblastoma.html. Accessed January 27th, 2020.
Definition / general
  • Mean age 55 to 58 years, range 23 to 80 years
  • Often vaginal or vulvar, may be cervical
  • Benign behavior but may recur after excision
  • May be neoplastic proliferation of hormonally responsive mesenchymal cells native to subepithelial stroma of endocervix and vulva of adult women
Gross description
  • Well circumscribed, polypoid or nodular mass, mean 3 cm (range 1 to 6 cm) arising in the superficial lamina propria of cervix and vagina
Microscopic (histologic) description
  • Well circumscribed cellular tumor composed of bland spindled and stellate mesenchymal cells in collagenous stroma with myxoid and edematous foci
  • Often lacelike pattern in hypocellular area, vague fascicular growth pattern in cellular area
  • Minimal mitotic activity
  • No atypical mitotic figures
Microscopic (histologic) images

Images hosted on other servers:

Breast: epithelioid type (H&E and CD34)

Breast: figure 1: sharply circumscribed tumor with fibrous pseudocapsule
2: composed of bland spindle cells in collagenous or myxoid stroma
3A: CD34+; 3B: bcl2+
4: desmin+ (focal)

Negative stains
Additional references
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