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Table of Contents
Definition / general | Gross description | Microscopic (histologic) description | Microscopic (histologic) images | Cytology description | Cytology images | Positive stainsCite this page: Radiation atypia . PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cervixradiationatypia.html. Accessed April 20th, 2018.
Definition / general
- Severe changes less than carcinoma
- Clinical history is important
- Can involve endocervical cells or squamous epithelial cells
Gross description
- Fibrosis, induration, stenosis of endocervix, surface irregularity or no abnormality
Microscopic (histologic) description
- Similar to changes in other organs (Int J Gynecol Pathol 1996;15:242)
- Hyalinized stroma or reactive changes with ectatic vessels
- Sparse, well spaced tubular or dilated glands in endocervix
- Abundant cytoplasm with vacuoles
- Uniformly dispersed nuclei with minimal crowding but marked nuclear atypia of endocervical glandular cells with enlarged, pleomorphic and smudged nuclei, prominent nucleoli
- Chromatin is fine and degenerated
- No / rare mitotic figures, low N/C ratio
Microscopic (histologic) images
Images hosted on PathOut server:
Radiation atypic
Images hosted on other servers:
Radiation atypic
Cytology description
- Usually low cellularity
- Multinucleated giant cells, large atypical cells with marked cytoplasmic vacuoles
- Intermediate parabasal cells have nuclear enlargement 2.5 to 3.0x normal but with low N/C ratio due to increased cytoplasm
- Chromatin is smudgy or finely granular
- Prominent nucleoli
- Smear also shows endothelial cells and macrophages (Diagn Cytopathol 1995;13:107) but clean background
Cytology images
Various images
Positive stains
- Scattered CEA
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