Radiation atypia

Cervix
Premalignant / preinvasive lesions
Radiation atypia

Topic Completed: 1 May 2007

Revised: 28 December 2018, last major update May 2007

Copyright: (c) 2007-2018, PathologyOutlines.com, Inc.

PubMed Search: Radiation atypia cervix

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Table of Contents

Cite this page: Perunovic B. Radiation atypia. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cervixradiationatypia.html. Accessed June 17th, 2019.

Definition / general

Severe changes less than carcinoma
Clinical history is important
Can involve endocervical cells or squamous epithelial cells

Gross description

Fibrosis, induration, stenosis of endocervix, surface irregularity or no abnormality

Microscopic (histologic) description

Similar to changes in other organs (Int J Gynecol Pathol 1996;15:242)
Hyalinized stroma or reactive changes with ectatic vessels
Sparse, well spaced tubular or dilated glands in endocervix
Abundant cytoplasm with vacuoles
Uniformly dispersed nuclei with minimal crowding but marked nuclear atypia of endocervical glandular cells with enlarged, pleomorphic and smudged nuclei, prominent nucleoli
Chromatin is fine and degenerated
No / rare mitotic figures, low N/C ratio

Microscopic (histologic) images

Images hosted on PathOut server:

Radiation atypic

Cytology description

Usually low cellularity
Multinucleated giant cells, large atypical cells with marked cytoplasmic vacuoles
Intermediate parabasal cells have nuclear enlargement 2.5 to 3.0x normal but with low N/C ratio due to increased cytoplasm
Chromatin is smudgy or finely granular
Prominent nucleoli
Smear also shows endothelial cells and macrophages (Diagn Cytopathol 1995;13:107) but clean background

Cytology images

Images hosted on other servers:

Various images

Positive stains

Scattered CEA