Premalignant / preinvasive lesions
Radiation atypia

Author: Branko Perunovic, M.D. (see Authors page)

Revised: 22 August 2018, last major update May 2007

Copyright: (c) 2007-2018, PathologyOutlines.com, Inc.

PubMed Search: Radiation atypia cervix

Cite this page: Perunovic, B. Radiation atypia. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cervixradiationatypia.html. Accessed October 15th, 2018.
Definition / general
  • Severe changes less than carcinoma
  • Clinical history is important
  • Can involve endocervical cells or squamous epithelial cells
Gross description
  • Fibrosis, induration, stenosis of endocervix, surface irregularity or no abnormality
Microscopic (histologic) description
  • Similar to changes in other organs (Int J Gynecol Pathol 1996;15:242)
  • Hyalinized stroma or reactive changes with ectatic vessels
  • Sparse, well spaced tubular or dilated glands in endocervix
  • Abundant cytoplasm with vacuoles
  • Uniformly dispersed nuclei with minimal crowding but marked nuclear atypia of endocervical glandular cells with enlarged, pleomorphic and smudged nuclei, prominent nucleoli
  • Chromatin is fine and degenerated
  • No / rare mitotic figures, low N/C ratio
Microscopic (histologic) images

Images hosted on PathOut server:

Radiation atypic

Cytology description
  • Usually low cellularity
  • Multinucleated giant cells, large atypical cells with marked cytoplasmic vacuoles
  • Intermediate parabasal cells have nuclear enlargement 2.5 to 3.0x normal but with low N/C ratio due to increased cytoplasm
  • Chromatin is smudgy or finely granular
  • Prominent nucleoli
  • Smear also shows endothelial cells and macrophages (Diagn Cytopathol 1995;13:107) but clean background
Cytology images

Images hosted on other servers:

Various images

Positive stains
  • Scattered CEA