Cervix
Sarcoma / lymphoma / other
Rhabdomyosarcoma (embryonal)

Author: Branko Perunovic, M.D. (see Authors page)

Revised: 27 April 2017, last major update May 2007

Copyright: (c) 2007-2017, PathologyOutlines.com, Inc.

PubMed Search: Rhabdomyosarcoma cervix [title]

Cite this page: Rhabdomyosarcoma (embryonal). PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cervixrhabdomyosarcoma.html. Accessed July 23rd, 2017.
Definition / general
  • Rhabdomyosarcomas are divided into embryonal, botryoid (subtype of embryonal), alveolar or pleomorphic (anaplastic) subtypes
  • Embryonal type is most common; occurs in children; more common in vagina than cervix
  • Cases in older women often contain cartilage and have better prognosis
Case reports
Embryonal rhabdomyosarcoma:

Other types:
Treatment
Gross description
  • Botryoid cases have protrusion of grape-like masses (due to edema and myxoid stroma) from cervix into vagina
  • Surface is glistening and translucent
Gross images

Images hosted on other servers:

Embryonal rhabdomyosarcoma

Microscopic (histologic) description
  • Botryoid - polypoid mass of rhabdomyoblasts at different maturational stages covered by attenuated epithelium; resembles vaginal tumor; often cambium layer beneath cervical epithelium in botryoid cases; often loose myxoid stroma, surface ulceration; may have cartilage in older women; variable mitotic rate
  • In young children, tumor cells may lack marked atypia and may blend in with normal, immature, cellular stroma
Microscopic (histologic) images

Images hosted on PathOut server:

Cambian layer and edematous stroma

Edematous stroma



Images hosted on other servers:

Embryonal RMS - various images

Cytology description
Positive stains
Differential diagnosis
  • Adenosarcoma: fibrous stroma so no grape-like clusters, no edematous, leaf-like pattern resembling phyllodes tumor
  • Edematous mesodermal polyp: adult women, small, soft fleshy protuberances up to 1.5 cm, stroma is uniform, no cambium layer, no rhabdomyoblasts, may have widely scattered atypical stromal cells
  • Yolk sac tumor