Mesenchymal / mixed epithelial & mesenchymal tumors

Topic Completed: 1 May 2007

Minor changes: 17 September 2020

Copyright: 2007-2020, PathologyOutlines.com, Inc.

PubMed Search: Rhabdomyosarcoma cervix [title]

Branko Perunovic, D.M.
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Cite this page: Perunovic B. Rhabdomyosarcoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cervixrhabdomyosarcoma.html. Accessed September 29th, 2020.
Definition / general
  • Rhabdomyosarcomas are divided into embryonal, botryoid (subtype of embryonal), alveolar or pleomorphic (anaplastic) subtypes
  • Embryonal type is most common; occurs in children; more common in vagina than cervix
  • Cases in older women often contain cartilage and have better prognosis
Case reports
Embryonal rhabdomyosarcoma:

Other types:
Gross description
  • Botryoid cases have protrusion of grape-like masses (due to edema and myxoid stroma) from cervix into vagina
  • Surface is glistening and translucent
Gross images

Images hosted on other servers:
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Embryonal rhabdomyosarcoma

Microscopic (histologic) description
  • Botryoid - polypoid mass of rhabdomyoblasts at different maturational stages covered by attenuated epithelium; resembles vaginal tumor; often cambium layer beneath cervical epithelium in botryoid cases; often loose myxoid stroma, surface ulceration; may have cartilage in older women; variable mitotic rate
  • In young children, tumor cells may lack marked atypia and may blend in with normal, immature, cellular stroma
Microscopic (histologic) images

Images hosted on PathOut server:

Cambian layer and edematous stroma

Edematous stroma

Cytology description
  • Loose clusters of spindled cells in a necrotic background; cells have mild nuclear atypia, thin nuclear membrane, fine chromatin pattern, partly clear nucleolus
Positive stains
Differential diagnosis
  • Adenosarcoma: fibrous stroma so no grape-like clusters, no edematous, leaf-like pattern resembling phyllodes tumor
  • Edematous mesodermal polyp: adult women, small, soft fleshy protuberances up to 1.5 cm, stroma is uniform, no cambium layer, no rhabdomyoblasts, may have widely scattered atypical stromal cells
  • Yolk sac tumor
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