Serous papillary adenocarcinoma

Author: Branko Perunovic , M.D. (see Authors page)

Revised: 4 May 2017, last major update May 2007

Copyright: (c) 2007-2017, PathologyOutlines.com, Inc.

PubMed Search: Serous papillary adenocarcinoma cervix

Cite this page: Serous papillary adenocarcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cervixserouspap.html. Accessed October 23rd, 2017.
Definition / general
  • Rare, resembles serous papillary carcinoma of ovary or endometrium
  • Metastasizes to pelvic and periaortic lymph nodes
  • Stage 1 tumors have similar outcome as other cervical adenocarcinomas; aggressive behavior if supradiaphragmatic metastases
  • In young women, may be focal component of conventional adenocarcinoma; HPV positive
  • In menopausal women, may be drop metastasis from endometrial or upper genital tract tumor; HPV negative
Case reports
Gross description
  • Resembles endocervical adenocarcinoma
Microscopic (histologic) description
  • Papillary proliferation of pleomorphic epithelial cells with complex papillary architecture on fibrovascular cores, exhibiting epithelial stratification and tufting; cells have protruding apical cytoplasm, moderate / severe nuclear atypia and nuclear pleomorphism
  • Frequent mitotic activity
  • Papillary cores often have intense inflammatory infiltrate
  • Often mixed with another adenocarcinoma, frequently low grade villoglandular
  • Psammoma bodies common
Microscopic (histologic) images

Images hosted on other servers:

H&E and p53

Uterus, not necessarily cervix

Cytology description
Positive stains
Differential diagnosis
  • Extension / metastatic ovarian or uterine tumors
Additional references