Cervix
Benign / nonneoplastic lesions
Squamous papilloma

Author: Zaibo Li, M.D. (see Authors page)

Revised: 2 September 2017, last major update August 2017

Copyright: (c) 2003-2017, PathologyOutlines.com, Inc.

PubMed Search: Squamous papilloma cervix

Cite this page: Li, Z. Squamous papilloma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cervixsquamouspapilloma.html. Accessed September 25th, 2017.
Definition / general
  • Benign polypoid lesion composed of a single papillary frond with a central fibrovascular core and mature squamous epithelium
Essential features
  • Composed of a single papillary frond with a central fibrovascular core and mature squamous epithelium Lacks the complex arborizing architecture, acanthosis and cellular atypia (koilocytes)
Epidemiology
  • Usually women of reproductive age
Sites
  • Lower genital tract (vagina, vulva, less commonly in cervix)
Etiology
  • Unknown but not HPV related
Clinical features
  • Usually asymptomatic but may be associated with burning or dyspareunia
Diagnosis
  • Composed of a single papillary frond with a central fibrovascular core and mature squamous epithelium
  • Lacks the complex arborizing architecture, acanthosis and cellular atypia of koilocytes
Treatment
  • Excision is curative
Gross description
  • May be single or multiple polypoid lesions, usually 5 mm or less
Microscopic (histologic) description
  • Composed of a single papillary frond with a central fibrovascular core and mature hyperplastic squamous epithelium
  • Lacks koilocytic features: complex arborizing architecture, acanthosis, cellular atypia, mitosis
Microscopic (histologic) images

Images hosted on PathOut server:

Not cervix:

Respiratory squamous papilloma



Images hosted on other servers:

Squamous epithelium overlying
fibrovascular papillae



Cytology description
  • Usually negative for abnormal / atypical cells
Differential diagnosis
Board review question #1
    Which of the following is true about squamous papilloma:

  1. It typically shows a complex arborizing architecture and acanthosis.
  2. It is a benign lesion with proliferation of squamous epithelium.
  3. It is a high risk HPV related lesion.
  4. Koilocytes are present.
Board review question #1
B. It is a benign lesion with proliferation of squamous epithelium.