Cervix
Benign / nonneoplastic epithelial lesions
Squamous papilloma

Editorial Board Member: Carlos Parra-Herran, M.D.

Topic Completed: 1 August 2017

Minor changes: 19 March 2020

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PubMed Search: Squamous papilloma cervix

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Cite this page: Li Z. Squamous papilloma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cervixsquamouspapilloma.html. Accessed July 8th, 2020.
Definition / general
  • Benign polypoid lesion composed of a single papillary frond with a central fibrovascular core and mature squamous epithelium
Essential features
  • Composed of a single papillary frond with a central fibrovascular core and mature squamous epithelium without complex arborizing architecture, acanthosis or cellular atypia (koilocytes)
Epidemiology
  • Usually women of reproductive age
Sites
  • Lower genital tract (vagina, vulva, less commonly in cervix)
Etiology
  • Unrelated to HPV infection
  • Predisposing factors unknown
Clinical features
  • Usually asymptomatic but may be associated with burning or dyspareunia
Diagnosis
  • Composed of a single papillary frond with a central fibrovascular core and mature squamous epithelium
  • Lacks the complex arborizing architecture, acanthosis and cellular atypia of koilocytes
Treatment
  • Excision is curative
Gross description
  • May be single or multiple polypoid lesions, usually 5 mm or less
Microscopic (histologic) description
  • Composed of a single papillary frond with a central fibrovascular core and mature hyperplastic squamous epithelium
  • Lacks koilocytic features: complex arborizing architecture, acanthosis, cellular atypia, mitosis
Cytology description
  • Usually negative for abnormal / atypical cells
Differential diagnosis
Board review style question #1
    Which of the following is true about squamous papilloma:

  1. It typically shows a complex arborizing architecture and acanthosis
  2. It is a benign lesion with proliferation of squamous epithelium
  3. It is a high risk HPV related lesion
  4. Koilocytes are present
Board review style question #1
B. It is a benign lesion with proliferation of squamous epithelium
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