Inflammatory / infectious

Topic Completed: 1 July 2015

Minor changes: 19 March 2020

Copyright: 2003-2020, PathologyOutlines.com, Inc.

PubMed Search: Tuberculosis [title] cervix

John K.S.S. Philip, M.D.
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Cite this page: Philip J, Salih Z. Tuberculosis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cervixtb.html. Accessed August 14th, 2020.
Definition / general
  • Relatively rare in Western countries including the USA but incidence is increasing with AIDS
  • Also called Koch disease
  • Most commonly affects the lungs, see topic
  • Genital tuberculosis is usually secondary to pulmonary tuberculosis
  • Within genital tract, most commonly affected organs are fallopian tubes (90%), endometrium (50%), ovary (10 - 30%) (Diagn Cytopathol 2009;37:592)
  • Caused mainly by Mycobacterium tuberculosis
Clinical features
Case reports
  • Antituberculosis therapy (also termed chemotherapy in this context)
  • Surgery may be needed for large tube ovarian abscess
Gross description
  • Cervical hypertrophy or ulceration
Microscopic (histologic) description
  • Pseudoepitheliomatous hyperplasia, noncaseating granulomas
Cytology description
  • Granulomas consisting of aggregates of epithelioid histiocytes
  • Histiocytes tend to be pink with vesicular and oval nuclei arranged in a syncytium with indistinct cytoplasmic borders
  • Langhans type multinucleated giant cells with 20 - 30 peripherally arranged vesicular nuclei may be seen
  • Variable numbers of lymphocytes are seen
  • Granular amorphous background matrix material indicates caseating necrosis
  • Heavy acute inflammatory exudate may be seen after secondary infection
Cytology images

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Epithelioid histiocytes

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Langhans giant cell

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Parabasal cells

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Ziehl Neelson

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Positive stains
  • Ziehl-Neelson and auramine-rhodamine (immunofluorescent) stains
Differential diagnosis
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