Urothelial carcinoma

Topic Completed: 1 May 2016

Revised: 20 February 2020

Copyright: 2002-2020, PathologyOutlines.com, Inc.

PubMed Search: Urothelial carcinoma [title]

Ashwyna Sunassee, M.D.
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Cite this page: Sunassee A. Urothelial carcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cervixurothelialca.html. Accessed April 9th, 2020.
Definition / general
  • Also known as transitional cell carcinoma
Essential features
  • Has a propensity for late metastasis and local recurrence
  • Potentially aggressive and presents at a more advanced stage
  • Post-menopausal women
  • Cervical epithelium, which is known to undergo benign transitional cell metaplasia, may give rise to benign and malignant transitional cell neoplasms (Am J Surg Pathol 1995;19:1138)
Clinical features
  • Post-menopausal bleeding or pelvic pain
Case reports
Microscopic (histologic) description
  • Can be papillary exophytic (most frequent) or inverted-endophytic
  • Papillary structures with thin fibrovascular cores
  • Ovoid cells with abundant eosinophilic cytoplasm (resembles urothelial epithelium)
  • Stromal invasion
Microscopic (histologic) images

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Low and high power views

Cytology description
Positive stains
Negative stains
Differential diagnosis
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