Villoglandular papillary adenocarcinoma (Cyto)

Author: Branko Perunovic (, M.D. (see Authors page)

Revised: 16 May 2017, last major update December 2013

Copyright: (c) 2007-2017, PathologyOutlines.com, Inc.

PubMed Search: Villoglandular papillary adenocarcinoma cervix

Cite this page: Villoglandular papillary adenocarcinoma (Cyto). PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cervixvilloglandular.html. Accessed October 20th, 2017.
Definition / general
  • Rare
  • Excellent prognosis only if pure; must examine carefully for squamous differentiation or other growth patterns (Eur J Obstet Gynecol Reprod Biol 1999;87:183); limit diagnosis to cases with minimal atypia and no other types of carcinoma
  • Metastases reported only rarely
  • Often in women age 40 years or less
Gross description
  • Exophytic polypoid lesion
Microscopic (histologic) images

Images hosted on PathOut server:

Tumor extends throughout most of cervix

Papillary fibrovascular cores lined by mildly atypical epithelium

Images hosted on other servers:

Papillary fibrovascular
cores lined by mildly
atypical epithelium

Adjacent area of higher grade adenocarcinoma

Positive stains
Differential diagnosis
  • Hyperplastic and reactive glands: no invasion, cells not cytologically malignant
  • Implant from endometrial tumor: see Int J Gynecol Cancer 2002;12:308
  • Other papillary carcinomas: smaller and thinner papillae, form a more complex lattice
Additional references