Chemistry, toxicology & urinalysis
Organ specific
Thryoid
T3 receptors


Topic Completed: 1 March 2011

Minor changes: 9 April 2020

Copyright: 2002-2020, PathologyOutlines.com, Inc.

PubMed Search: T3 receptors [title]

Nat Pernick, M.D.
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Cite this page: Pernick N. T3 receptors. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/chemistryT3receptors.html. Accessed July 7th, 2020.
Definition / general
  • 4 isoforms: Alpha1, Alpha2, Beta1, Beta2
  • Alpha1, Alpha2 and Beta1 receptors are present in most tissue, bind T3 to promote protein synthesis
  • Beta2 receptor is unique to anterior pituitary gland, hypothalamus and developing ear
    • Mediates negative feedback of TSH (Mol Endocrinol 2005;19:1529)
    • Mutations cause thyroid hormone resistance with varying degrees of hypothyroidism
  • Alpha2 receptor is inhibitory
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