Chemistry
Thyroid related
T3 receptors

Author: Nat Pernick, M.D. (see Authors page)

Revised: 23 February 2016, last major update March 2011

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed Search: T3 receptors [title]
Definition / General
  • 4 isoforms: Alpha1, Alpha2, Beta1, Beta2
  • Alpha1, Alpha2 and Beta1 receptors are present in most tissue, bind T3 to promote protein synthesis
  • Beta2 receptor is unique to anterior pituitary gland, hypothalamus and developing ear
    • Mediates negative feedback of TSH (Mol Endocrinol 2005;19:1529)
    • Mutations cause thyroid hormone resistance with varying degrees of hypothyroidism
  • Alpha2 receptor is inhibitory