Thyroid related
T3 receptors

Topic Completed: 1 March 2011

Revised: 31 December 2018, last major update March 2011

Copyright: (c) 2002-2016,, Inc.

PubMed Search: T3 receptors [title]

Nat Pernick, M.D.
Page views in 2018: 22
Page views in 2019 to date: 23
Cite this page: Pernick N. T3 receptors. website. Accessed December 13th, 2019.
Definition / general
  • 4 isoforms: Alpha1, Alpha2, Beta1, Beta2
  • Alpha1, Alpha2 and Beta1 receptors are present in most tissue, bind T3 to promote protein synthesis
  • Beta2 receptor is unique to anterior pituitary gland, hypothalamus and developing ear
    • Mediates negative feedback of TSH (Mol Endocrinol 2005;19:1529)
    • Mutations cause thyroid hormone resistance with varying degrees of hypothyroidism
  • Alpha2 receptor is inhibitory
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