Thyroid related
Calcium stimulation test for calcitonin

Topic Completed: 1 March 2011

Revised: 31 December 2018, last major update March 2011

Copyright: (c) 2002-2016,, Inc.

PubMed Search: Calcium stimulation test [title] calcitonin

Nat Pernick, M.D.
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Cite this page: Pernick N. Calcium stimulation test for calcitonin. website. Accessed January 21st, 2020.
Definition / general
  • A provocative test to expose C cell abnormalities, since it increases calcitonin at all stages of medullary thyroid carcinoma
  • Has been replaced by genetic testing
  • May be less sensitive than pentagastrin stimulation test

  • Give 2.5 mg/kg of calcium gluconate over 30 seconds, collect blood at time 0, 1, 2 and 5 minutes to determine calcitonin levels
  • Rise in calcitonin > 100 ng/L suggests early medullary thyroid carcinoma
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