Chemistry
Thyroid related
Pentagastrin stimulation test

Author: Nat Pernick, M.D. (see Authors page)

Revised: 23 February 2016, last major update March 2011

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed Search: Pentagastrin stimulation test [title]
Table of Contents
Laboratory | Interpretation
Laboratory
Indications

Methodology
  • Give 0.5 μg/kg body weight of pentagastrin IV over 5 minutes, collect blood at time 0, 1, 2, 5 and 10 minutes and measure calcitonin levels
Interpretation
  • 50 - 100 ng/L indicates possible medullary thyroid carcinoma or other pathology
  • >100 ng/L indicates probable medullary thyroid carcinoma (J Clin Endocrinol Metab 2007;92:450)
  • Baseline or post-pentagastrin values > 10 ng/L indicates C cell pathology in MEN2 or residual tissue in medullary thyroid carcinoma patients after surgery

  • Limitations
  • Adverse effects
    • Substernal discomfort, nausea, vomiting, metallic taste, abdominal cramping, flushing, warmth, urgency, esophageal spasm, tachycardia, headache (Clin Chem 2002;48:1505)