Chemistry
Thyroid related
Reverse T3

Author: Nat Pernick, M.D. (see Authors page)

Revised: 23 February 2016, last major update March 2011

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed Search: Reverse T3 [title]
Table of Contents
Definition / General | Laboratory
Definition / General
  • Major metabolite of T4
  • 40% of T4 is 5 deiodinated (by 5-deiodinase) peripherally to form reverse T3
  • No biologic activity
  • Half life is 4 hours (short)
  • Bound to thyroid binding globulin
  • Wilson syndrome:
    • Questionable entity with no supporting publications (to date) of reverse T3 dominance causing hypothyroidism and low body temperature
Laboratory
Indications

High levels