Thyroid related
Reverse T3

Topic Completed: 1 March 2011

Revised: 31 December 2018, last major update March 2011

Copyright: (c) 2002-2016,, Inc.

PubMed Search: Reverse T3 [title]

Nat Pernick, M.D.
Page views in 2018: 97
Page views in 2019 to date: 89
Table of Contents
Definition / general | Laboratory
Cite this page: Pernick N. Reverse T3. website. Accessed September 19th, 2019.
Definition / general
  • Major metabolite of T4
  • 40% of T4 is 5 deiodinated (by 5-deiodinase) peripherally to form reverse T3
  • No biologic activity
  • Half life is 4 hours (short)
  • Bound to thyroid binding globulin
  • Wilson syndrome:
    • Questionable entity with no supporting publications (to date) of reverse T3 dominance causing hypothyroidism and low body temperature

High levels
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