Thyroid related
Thyroperoxidase antibody (Anti-TPO)

Author: Nat Pernick, M.D. (see Authors page)

Revised: 23 February 2016, last major update March 2011

Copyright: (c) 2002-2016,, Inc.

PubMed Search: Thyroperoxidase antibody [title]
Cite this page: Thyroperoxidase antibody (Anti-TPO). website. Accessed November 17th, 2018.
Definition / general
  • Associated with Hashimoto's thyroiditis (90%) and Graves disease (75%), although also present in women with no clinical disease
  • Antibody is directed against antigen within microsomal fraction of thyroid epithelial cells
  • Methodology:
    • Previously indirect immunofluorescence microscopy with substrate of air dried human or cryostat monkey tissue, looking for cytoplasmic but not nuclear staining of thyroid follicular cells
    • Concordance between automated methods needs improvement (Clin Chim Acta 2007;376:88)
  • Does not predict relapse of Graves disease after carbimazole treatment withdrawal (Thyroid 2006;16:1041)
Differential diagnosis