Chemistry
Thyroid related
Thyroid stimulating hormone receptor antibody


Topic Completed: 1 March 2011

Revised: 31 December 2018, last major update March 2011

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PubMed Search: Thyroid stimulating hormone receptor antibody [title]

Nat Pernick, M.D.
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Cite this page: Pernick N. Thyroid stimulating hormone receptor antibody. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/chemistrytshreceptor.html. Accessed October 19th, 2019.
Definition / general
  • Also called TRAb (TSH Receptor Antibody)
  • Previously called thyroid stimulating immunoglobulin or long acting thyroid stimulators (LATS)
  • Present in 85 - 95% with Graves disease
  • Either stimulating (causing hyperthyroidism), blocking (usually no clinical impact) or no effect
  • Antibodies cross placenta and may cause thyroid dysfunction in newborns
Laboratory
Indications
  • Not for routine clinical testing
  • To confirm Graves disease in difficult cases, monitor hormone replacement therapy, diagnose neonatal thyrotoxicosis

Methodology
  • Thyrotropin binding inhibiting immunoglobulin technique, RIA

Reference ranges
  • Negative: 0 - 9%
  • Indeterminate: 10 - 15%
  • Positive: 16% or more
Interpretation
  • Positive results are consistent with autoimmune disease
  • Low antibody titer before drug therapy for Graves disease is a good prognostic factor for remission after drug therapy (Horm Metab Res 2004;36:92) or relapse (Horm Metab Res 2007;39:56), predicts risk of thyroid dysfunction in newborns of mothers with Graves disease
Additional references
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