Molecular markers
Translocations / cytogenetics abnormalities
Cytogenetics - general

Topic Completed: 1 February 2014

Revised: 15 February 2019

Copyright: 2003-2018,, Inc.

PubMed Search: Translocations cytogenetics[TI] abnormalities

Nat Pernick, M.D.
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Table of Contents
Definition / general
Cite this page: Pernick N. Cytogenetics - general. website. Accessed September 23rd, 2019.
Definition / general
  • Useful particularly for leukemia, lymphoma, germ cell tumors and soft tissue tumors
  • Analysis requires fresh tissue transported in sterile transport medium
  • Tissue is disaggregated, cultured, harvested and placed on a slide; chromosomes are spread out, stained with Giemsa and examined
  • Interphase cytogenetics: does not require fresh tissue; techniques include chromosome painting (uses chromosome specific probes), use of centromeric probes, use of cosmid probes
  • Translocations may be due to aberrant V(D)J recombinase activity in lymphocytes (Arch Pathol Lab Med 2003;127:1148)
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