CNS tumor
Cytopathology competency assessment
Variants of glial tumors

Topic Completed: 1 September 2012

Revised: 3 January 2019, last major update September 2012

Copyright: (c) 2002-2017,, Inc.

PubMed Search: CNS cytopathology glial tumor variants

Gordon H. Yu, M.D.
Page views in 2018: 62
Page views in 2019 to date: 38
Cite this page: Yu G. Cytopathology competency assessment - variants of glial tumors. website. Accessed October 22nd, 2019.
Medical knowledge, practice based learning and systems based practice
  1. Pilocytic astrocytoma (PA)
    1. Learn the typical clinical presentation of PA, including the expected clinical behavior of this primary neoplasm as compared with other gliomas (i.e. diffuse astrocytoma)
    2. Learn the most common anatomic locations of PA and its typical imaging findings
    3. Recognize cytomorphologic features seen in PA and its differential diagnosis, including the presence of Rosenthal fibers and eosinophilic granular bodies
    4. Recognize the possibility of other cytologic findings, including pseudorosettes, microcalcifications, anisonucleosis and degenerative atypia
  2. Pleomorphic xanthoastrocytoma (PXA)
    1. Identify the typical anatomic location of PXA and the affected patient population
    2. Identify typical radiologic findings of PXA and differences in treatment approaches when compared with malignant gliomas
    3. Recognize typical cytomorphologic features of PXA and its differentiation from other neoplastic lesions
  3. Small cell glioblastoma multiforme (SCGBM)
    1. Learn cytomorphologic features of SCGBM, immunohistochemical findings and results of molecular studies
  4. Gliosarcoma (GS)
    1. Recognize the definition of GS, its incidence and characteristic cytomorphologic features
    2. Identify molecular mutations which may be observed in GS
  5. Granular cell astrocytoma (GCA)
    1. Recognize imaging findings seen in GCA and its expected clinical behavior
    2. Learn the cytomorphologic features of GCA as well as the role of immunohistochemical staining in its differential diagnosis
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