CNS tumor
Embryonal tumors
Ganglioneuroblastoma

Deputy Editor-in-Chief: Debra Zynger, M.D.
Nirupama Singh, M.D., Ph.D.
Paul J. Biggs, M.D.

Topic Completed: 1 January 2018

Revised: 14 December 2019

Copyright: 2002-2019, PathologyOutlines.com, Inc.

PubMed Search: ganglioneuroblastoma CNS

Nirupama Singh, M.D., Ph.D.
Paul J. Biggs, M.D.
Page views in 2019: 690
Page views in 2020 to date: 204
Cite this page: Singh, N. Ganglioneuroblastoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cnsganglioneuroblastoma.html. Accessed April 8th, 2020.
Definition / general
  • Similar to other embryonal tumors, ganglioneuroblastoma is characterized by:
    • Poorly differentiated neuroepithelial cells
    • Groups of neurocytic and ganglion cells where dystrophic ganglion cells are prominent features
Essential features
  • Ganglion cells are a prominent feature
ICD coding
  • C71: malignant neoplasm of brain
Radiology images

Images hosted on other servers:

Xray of ultiple nodules scattered in lungs

Echocardiogram of multiple metastatic lesions

Noncontrast CT of paravertebral area

Case reports
Clinical images

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Blueberry lesions

Microscopic (histologic) description
  • Ganglioneuromatous tissue in the background of neuropil and nests of neuroblasts
  • Neuroblasts in various stages of maturation, dominated by differentiating neuroblasts
Microscopic (histologic) images

Images hosted on PathOut server:

Images contributed by Nirupama Singh M.D., Ph.D.

Ganglion cells surrounded by neuroblast cells

multinucleated ganglion cells

Ganglion cells with cytoplasm and neuroblasts



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Differentiating neuroblasts

Cytology images

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Giemsa stain 400x

Positive stains
Differential diagnosis
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