CNS tumor
Embryonal tumors
Other embryonal tumors
Ganglioneuroblastoma

Deputy Editor-in-Chief: Debra Zynger, M.D.
Nirupama Singh, M.D., Ph.D.
Paul J. Biggs, M.D.

Topic Completed: 1 January 2018

Minor changes: 28 September 2020

Copyright: 2002-2020, PathologyOutlines.com, Inc.

PubMed Search: ganglioneuroblastoma CNS

Nirupama Singh, M.D., Ph.D.
Paul J. Biggs, M.D.
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Cite this page: Singh N, Biggs PJ. Ganglioneuroblastoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cnsganglioneuroblastoma.html. Accessed September 29th, 2020.
Definition / general
  • Similar to other embryonal tumors, ganglioneuroblastoma is characterized by:
    • Poorly differentiated neuroepithelial cells
    • Groups of neurocytic and ganglion cells where dystrophic ganglion cells are prominent features
Essential features
  • Ganglion cells are a prominent feature
ICD coding
  • C71: malignant neoplasm of brain
Radiology images

Images hosted on other servers:

Xray of ultiple nodules scattered in lungs

Echocardiogram of multiple metastatic lesions

Noncontrast CT of paravertebral area

Case reports
Clinical images

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Blueberry lesions

Microscopic (histologic) description
  • Ganglioneuromatous tissue in the background of neuropil and nests of neuroblasts
  • Neuroblasts in various stages of maturation, dominated by differentiating neuroblasts
Microscopic (histologic) images

Contributed by Nirupama Singh, M.D., Ph.D.

Ganglion cells surrounded by neuroblast cells

multinucleated ganglion cells

Ganglion cells with cytoplasm and neuroblasts

Cytology images

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Giemsa stain 400x

Positive stains
Differential diagnosis
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