CNS tumor
Lymphoma and other hematopoietic lesions
Langerhans cell histiocytosis




Topic Completed: 1 January 2006

Revised: 3 January 2019, last major update January 2006

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PubMed Search: Langerhans cell histiocytosis [title] CNS

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Cite this page: Pernick N. Langerhans cell histiocytosis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cnstumorLCH.html. Accessed May 26th, 2019.
Definition / general
  • Rare lytic skull lesion or parasellar mass
  • Children and young adults
  • May arise from primary histiocytic proliferation with secondary atrophy or from demyelination and gliosis of unknown origin (J Child Neurol 2000;15:150)
Case reports
Microscopic (histologic) description
  • Cells with abundant eosinophilic cytoplasm and reniform (kidney / coffee bean shaped) nuclei with grooves
  • Variable collagen, gliosis and infiltrating T cells
  • May be partially infiltrative of surrounding CNS parenchyma or circumscribed granulomas
Microscopic (histologic) images

Images hosted on other servers:

Various images

Positive stains
Negative stains
Electron microscopy description
  • Birbeck granules
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