CNS tumor
Astrocytic tumors
Anaplastic astrocytoma



Topic Completed: 1 February 2012

Revised: 16 September 2019

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: "Anaplastic astrocytoma" CNS


Eman Abdelzaher, M.D., Ph.D.
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Cite this page: Abdelzaher E. Anaplastic astrocytoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cnstumoranaplasticastrocytoma.html. Accessed September 23rd, 2019.
Epidemiology
  • Mean age 45 years; male predominance
Sites
  • Usually supratentorial but can be anywhere in CNS; preferred sites are frontal and temporal lobes, brain stem, spinal cord; uncommon in cerebellum
Clinical features
Grading
  • WHO grade III
Radiology description
  • Neuroimaging: usually heterogeneous or patchy enhancement
Radiology images

Images hosted on other servers:

Anaplastic astrocytoma

Case reports
Gross description
  • Ill defined with blurred margins, may have spongy or gelatinous appearance, microcysts, calcification
  • May have clearer distinction from surrounding brain structures than low grade diffuse astrocytomas
Gross images

Images hosted on other servers:

Various images

Microscopic (histologic) description
  • Similar to grade II tumors but more cellular, more atypia and mitoses are seen
  • By definition, vascular proliferation and necrosis are absent
Microscopic (histologic) images

Images hosted on other servers:

Various images

H&E and HAM56+ macrophages

p53

Positive stains
Molecular / cytogenetics description
Differential diagnosis
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