CNS tumor
Ependymal tumors
Anaplastic ependymoma

Topic Completed: 1 August 2012

Revised: 2 January 2019, last major update August 2012

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Anaplastic ependymoma [title]

Eman Abdelzaher, M.D., Ph.D.
Page views in 2019: 4,731
Page views in 2020 to date: 1,043
Cite this page: Abdelzaher E. Anaplastic ependymoma. website. Accessed March 28th, 2020.
Definition / general
  • Grade III of IV
  • Rare; usually infants and children
  • Often cerebrum or cerebellum of children / young adults but all ages and locations
  • Infiltrates leptomeninges, spreads along CSF pathways like medulloblastoma
Case reports
Microscopic (histologic) description
  • Marked hypercellularity, nuclear atypia and brisk mitotic activity
  • May have intramural or glomeruloid vascular proliferation, pseudopalisading necrosis, perivascular rosettes
  • Discrete or infiltrative margin
  • Nonpalisading necrosis is not sufficient for diagnosis in otherwise low grade ependymoma
Microscopic (histologic) images

Images hosted on PathOut server:

Images contributed by Dr. Roopa Arora, Case of the Week #427:







Images hosted on other servers:

Focally hypercellular

Various images

Brisk mitotic rate

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