CNS tumor
Ependymal tumors
Anaplastic ependymoma

Author: Eman Abdelzaher, M.D., Ph.D. (see Authors page)

Revised: 29 August 2017, last major update August 2012

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Anaplastic ependymoma [title]

Cite this page: Abdelzaher, E. Anaplastic ependymoma. website. Accessed July 17th, 2018.
Definition / general
  • Grade III of IV
  • Rare; usually infants and children
  • Often cerebrum or cerebellum of children / young adults but all ages and locations
  • Infiltrates leptomeninges, spreads along CSF pathways like medulloblastoma
Case reports
Microscopic (histologic) description
  • Marked hypercellularity, nuclear atypia and brisk mitotic activity
  • May have intramural or glomeruloid vascular proliferation, pseudopalisading necrosis, perivascular rosettes
  • Discrete or infiltrative margin
  • Nonpalisading necrosis is not sufficient for diagnosis in otherwise low grade ependymoma
Microscopic (histologic) images

Images hosted on PathOut server:

Images contributed by Dr. Roopa Arora, Case of the Week #427:







Images hosted on other servers:

Focally hypercellular

Various images

Brisk mitotic rate