Reviewer: Eman Abdelzaher, M.D., Ph.D. (see Reviewers page)
Revised: 22 April 2013, last major update August 2012
Copyright: (c) 2005-2013, PathologyOutlines.com, Inc.
- Grade III of IV
- Rare; usually infants and children
- Often cerebrum or cerebellum of children / young adults, but all ages and locations
- Infiltrates leptomeninges, spreads along CSF pathways like medulloblastoma
- Marked hypercellularity, nuclear atypia and brisk mitotic activity
- May have intramural or glomeruloid vascular proliferation, pseudopalisading necrosis, perivascular rosettes
- Discrete or infiltrative margin
- Non-palisading necrosis is not sufficient for diagnosis in otherwise low grade ependymoma
Brisk mitotic rate
End of CNS tumor > Ependymal tumors > Anaplastic ependymoma
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