CNS tumor
Lymphoma and other hematopoietic lesions
Anaplastic large cell lymphoma

Topic Completed: 1 January 2006

Revised: 22 November 2019

Copyright: (c) 2002-2019,, Inc.

PubMed Search: "Anaplastic large cell lymphoma" CNS

Nat Pernick, M.D.
Page views in 2018: 157
Page views in 2019 to date: 225
Cite this page: Pernick N. Anaplastic large cell lymphoma. website. Accessed December 6th, 2019.
Definition / general
  • Rare in CNS (either primary or secondary)
  • Aggressive (rapidly fatal)
  • Favorable prognostic factors: ALK1+, young age (Am J Surg Pathol 2003;27:487)
Case reports
Microscopic (histologic) description
  • Large lymphoid cells with abundant cytoplasm and pleomorphic nuclei, often horseshoe or kidney shaped
  • Usually necrosis and mitotic activity
  • Variants include small cell and lymphohistiocytic
Microscopic (histologic) images

Images hosted on other servers:

H&E, stains and molecular studies

Medium to large cells

Positive stains
Molecular / cytogenetics description
  • T cell receptor gene rearrangements
  • t(2;5) involving ALK1 and NPM
Differential diagnosis
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