CNS tumor
Neuroepithelial tumors of uncertain origin
Angiocentric glioma




Topic Completed: 1 March 2013

Revised: 2 January 2019, last major update March 2013

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: Angiocentric glioma



Eman Abdelzaher, M.D., Ph.D.
Page views in 2018: 924
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Cite this page: Abdelzaher E. Angiocentric glioma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cnstumorangiocentricglioma.html. Accessed June 18th, 2019.
Definition / general
  • Superficial cerebrocortical tumour with features of infiltrating astrocytoma and ependymoma
  • Relationship to ependymoma is unclear
Epidemiology
  • Primarily children and young adults
  • Wide age range (2 to 70 years, mean 17 years)
  • Affect both sexes equally
Clinical features
  • Seizures are characteristic
Grading
  • WHO grade I
  • Criteria for higher grade lesions are unclear
Radiology description
  • Well delineated, solid, hyperintense, nonenhancing cortical lesions
  • Stalk-like extension to adjacent ventricle is diagnostic
Radiology images

Images hosted on other servers:

Axial MR images

Axial T1 and T2 weighted MR images

Hyperintense cortically based mass

Prognostic factors
  • Generally favorable with rare recurrence
Case reports
Treatment
  • Surgical excision
  • Role of chemo or radiotherapy is unclear
Gross description
  • Ill defined, firm
Microscopic (histologic) description
  • Infiltrative, monomorphous, bipolar spindled cells arranged in angiocentric pattern about cortical blood vessels
  • Also ependymoma-like pseudorosettes, subpial palisading, accumulation of tumor cells, miniature schwannoma-like nodules
  • Usually no mitoses, no vascular proliferation, no necrosis
  • Mitotically active lesions are associated with increased risk of recurrence
Microscopic (histologic) images

Images hosted on other servers:

Various images

Small clusters of monomorphous cells

GFAP and EMA

Virtual slides

Images hosted on other servers:

24 year old woman with seizures

Positive stains
  • EMA (dot-like microlumina, focal surface), variable GFAP
Differential diagnosis
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