CNS tumor
Lymphoma and other hematopoietic lesions
Angiotropic lymphoma



Topic Completed: 1 January 2006

Revised: 3 January 2019, last major update January 2006

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PubMed Search: Angiotropic lymphoma [title]


Nat Pernick, M.D.
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Cite this page: Pernick N. Angiotropic lymphoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cnstumorangiotropiclymphoma.html. Accessed October 21st, 2019.
Definition / general
  • Also called malignant angioendotheliomatosis, intravascular lymphoma
  • Uncommon cause of primary CNS lymphoma
  • Presents as rapidly progressive dementia with multifocal neurologic deficits, usually ages 60+ years
  • Mean survival 9 - 13 months
  • May present with CNS mass lesion (Pathol Int 2004;54:231)
Case reports
Treatment
  • Chemotherapy may be curative
Microscopic (histologic) description
  • Large, noncohesive, pleomorphic lymphoid cells (diffuse large B cell lymphoma type) within small and intermediate blood vessels
Microscopic (histologic) images

Images hosted on other servers:

Intravascular tumor cells are CD20+

Positive stains
  • CD45, usually B cell markers
  • Also bcl2
Differential diagnosis
Additional references
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