CNS tumor
Lymphoma and other hematopoietic lesions
Angiotropic lymphoma

Author: Nat Pernick, M.D. (see Authors page)

Revised: 7 September 2017, last major update January 2006

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: Angiotropic lymphoma [title]

Cite this page: Pernick, N. Angiotropic lymphoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cnstumorangiotropiclymphoma.html. Accessed December 13th, 2017.
Definition / general
  • Also called malignant angioendotheliomatosis, intravascular lymphoma
  • Uncommon cause of primary CNS lymphoma
  • Presents as rapidly progressive dementia with multifocal neurologic deficits, usually ages 60+ years
  • Mean survival 9 - 13 months
  • May present with CNS mass lesion (Pathol Int 2004;54:231)
Case reports
Treatment
  • Chemotherapy may be curative
Microscopic (histologic) description
  • Large, noncohesive, pleomorphic lymphoid cells (diffuse large B cell lymphoma type) within small and intermediate blood vessels
Microscopic (histologic) images

Images hosted on other servers:

Intravascular tumor cells are CD20+

Positive stains
  • CD45, usually B cell markers
  • Also bcl2
Differential diagnosis
Additional references