CNS tumor
Lymphoma and other hematopoietic lesions
Angiotropic lymphoma

Topic Completed: 1 January 2006

Revised: 3 January 2019, last major update January 2006

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Angiotropic lymphoma [title]

Nat Pernick, M.D.
Page views in 2018: 229
Page views in 2019 to date: 307
Cite this page: Pernick N. Angiotropic lymphoma. website. Accessed December 6th, 2019.
Definition / general
  • Also called malignant angioendotheliomatosis, intravascular lymphoma
  • Uncommon cause of primary CNS lymphoma
  • Presents as rapidly progressive dementia with multifocal neurologic deficits, usually ages 60+ years
  • Mean survival 9 - 13 months
  • May present with CNS mass lesion (Pathol Int 2004;54:231)
Case reports
  • Chemotherapy may be curative
Microscopic (histologic) description
  • Large, noncohesive, pleomorphic lymphoid cells (diffuse large B cell lymphoma type) within small and intermediate blood vessels
Microscopic (histologic) images

Images hosted on other servers:

Intravascular tumor cells are CD20+

Positive stains
  • CD45, usually B cell markers
  • Also bcl2
Differential diagnosis
Additional references
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