CNS tumor
Meningeal tumors
Chordoid meningioma

Author: Jesse Kresak, M.D. (see Authors page)
Editor: Anthony T. Yachnis, M.D.

Revised: 6 September 2017, last major update January 2015

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Chordoid meningioma [title]

Cite this page: Kresak, J. Chordoid meningioma. website. Accessed July 17th, 2018.
Definition / general
  • WHO grade II due to tendency to recur
  • < 1% of all meningiomas
  • Usually adults (mean age 47 years) with no systemic symptoms
  • Cases in young adults / pediatric population may be associated with hematologic conditions, such as Castleman disease
  • 80% are supratentorial but also infratentorial, intraventricular, in spinal cord and optic nerve
Radiology images

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Enlarged residual tumor

Prognostic factors
Case reports
  • Gross total resection when possible
  • Postoperative radiation often added for subtotal resections
Gross description
  • Dural based
  • Well circumscribed
Microscopic (histologic) description
  • Called "chordoid" because it resembles a chordoma, with cords or trabeculae of epithelioid cells that may be eosinophilic or clear (resembling physaliferous cells) within a mucin rich or myxoid stroma
  • Often traditional meningioma features are intermixed
  • Contains a variable lymphoplasmacytic infiltrate
Microscopic (histologic) images

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Contributed by Jesse Kresak, M.D.

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Cells arranged in cords with a myxoid background

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Clear cytoplasm in myxoid stroma

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trabeculae of
eosinophilic cells

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Stroma is Alcian blue+

Cytology description
  • Cords of polygonal tumor cells with bland nuclei and nuclear pseudoinclusions
  • Occasional loose cells with abundant metachromatic pink purple cells without cytoplasmic vacuoles
  • Also lymphoplasmacytic infiltrate (Acta Cytol 2004;48:259, Acta Cytol 2004;48:397)
Cytology images

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Vacuolated cells

Positive stains
Negative stains
Differential diagnosis
Additional references