CNS tumor
Mesenchymal and other tumors

Topic Completed: 1 January 2006

Minor changes: 14 December 2019

Copyright: 2002-2019,, Inc.

PubMed Search: Chordoma[title] CNS tumor "loattrfree full text"[sb]

Nat Pernick, M.D.
Page views in 2019: 4,811
Page views in 2020 to date: 2,226
Cite this page: Pernick N. Chordoma. website. Accessed May 30th, 2020.
Definition / general
Diagrams / tables

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Drawing of clival chordoma

Radiology images

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Sagittal MRI of sacral tumor

Prognostic factors
  • Poor prognostic factors: large tumor size, positive surgical margins, tumor necrosis, high proliferative activity and areas of dedifferentiation; also up regulation of N cadherin and down regulation of E cadherin (Am J Surg Pathol 2005;29:1422)
Case reports
Gross description
  • Soft, gelatinous, hemorrhagic and gray tumor
Microscopic (histologic) description
  • Cords and lobules of physaliferous (having bubbles or vacuoles) cells separated by fibrous septa with extensive myxoid stroma
  • Cells may be very large, with vacuolated cytoplasm and prominent vesicular nucleus (Arch Pathol Lab Med 2004;128:1457)
  • Also small tumor cells with small nucleus; rare mitotic figures
Microscopic (histologic) images

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Sacral tumor



Alcian blue

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Neural type cadherin (fig 2D)

Cytology images

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Diff Quik

Positive stains
Electron microscopy description
Molecular / cytogenetics description
  • Aneuploid
Differential diagnosis
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