CNS tumor
Mesenchymal and other tumors
Chordoma

Author: Nat Pernick, M.D. (see Authors page)

Revised: 11 September 2017, last major update January 2006

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: Chordoma[title] CNS tumor "loattrfree full text"[sb]

See also: Chondroid chordoma
Cite this page: Pernick, N. Chordoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cnstumorchordoma.html. Accessed October 21st, 2017.
Definition / general
Diagrams / tables

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Drawing of clival chordoma

Radiology images

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Sagittal MRI of sacral tumor

Prognostic factors
  • Poor prognostic factors: large tumor size, positive surgical margins, tumor necrosis, high proliferative activity and areas of dedifferentiation; also up regulation of N cadherin and down regulation of E cadherin (Am J Surg Pathol 2005;29:1422)
Case reports
Treatment
Gross description
  • Soft, gelatinous, hemorrhagic and gray tumor
Microscopic (histologic) description
  • Cords and lobules of physaliferous (having bubbles or vacuoles) cells separated by fibrous septa with extensive myxoid stroma
  • Cells may be very large, with vacuolated cytoplasm and prominent vesicular nucleus (Arch Pathol Lab Med 2004;128:1457)
  • Also small tumor cells with small nucleus; rare mitotic figures
Microscopic (histologic) images

Images hosted on PathOut server:

Sacral tumor

Pankeratin

Synaptophysin

Alcian blue



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Incipient chordoma

Benign notocordal cell tumor

Neural type cadherin (fig 2D)

Cytology images

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Diff Quik

Positive stains
Electron microscopy description
Molecular / cytogenetics description
  • Aneuploid
Differential diagnosis