CNS tumor
Choroid plexus tumors
Choroid plexus carcinoma

Author: Nat Pernick, M.D. (see Authors page)

Revised: 1 September 2017, last major update January 2006

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: Choroid plexus carcinoma [title]

Cite this page: Pernick, N. Choroid plexus carcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cnstumorchoroidplexuscarcinoma.html. Accessed November 23rd, 2017.
Definition / general
  • WHO grade III of IV
  • Extremely rare
  • Resembles metastatic carcinoma but usually occurs in children
  • Associated with germline p53 mutations (Eur J Cancer 2005;41:1597)
Case reports
Gross description
  • Well circumscribed, brown red, cauliflower-like mass
  • Variable hemorrhage, necrosis and invasiveness
Microscopic (histologic) description
  • Sheets of anaplastic tumor cells with necrosis, frequent mitotic figures
  • Focal papillary areas resemble papilloma but with more crowded and elongated cells
Microscopic (histologic) images

Images hosted on other servers:

Predominately papillary or filiform architecture

Bizarre nuclei, brisk mitotic rate

Low molecular weight keratin

GFAP (focal)

Transthyretin

Positive stains
Differential diagnosis