CNS tumor
Choroid plexus tumors
Choroid plexus papilloma



Topic Completed: 1 January 2006

Revised: 2 January 2019, last major update January 2006

Copyright: (c) 2002-2018, PathologyOutlines.com, Inc.

PubMed Search: "Choroid plexus papilloma" CNS


Nat Pernick, M.D.
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Cite this page: Pernick N. Choroid plexus papilloma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cnstumorchoroidplexuspapillomas.html. Accessed November 20th, 2019.
Definition / general
  • Grade I of IV - benign
  • Rare ( < 1% of intracranial neoplasms), slow growing tumor commonly in ventricular system and associated with hydrocephalus due to excess production of CSF or direct tumor obstruction of CSF flow
  • Often causes developmental delay, behavioral problems or epilepsy in children
  • 85% occur at age 10 years or less; often present at birth
  • Needle biopsy not recommended since histologically resembles normal choroid plexus
  • 10 - 30% become histologically malignant
  • High survival unless becomes malignant (then 5 year survival is 26%) although histology does not predict behavior
Case reports
Gross description
  • Larger than normal choroid plexus
  • Lobulated encapsulated mass
Gross images

Images hosted on other servers:

Fourth ventricle tumor

Microscopic (histologic) description
  • Resembles normal choroid plexus with single layer of epithelial cells overlying a fibrovascular core
  • Epithelial cells are more crowded and piled up than normal
  • Mild atypia
  • May be pigmented, oncocytic, osteogenic, adenomatous, acinar, mucus secreting, tubular
  • May have vascular stalk that provides mobility within ventricular system
Microscopic (histologic) images

Images hosted on other servers:

Papillary architecture at low power

Cuboidal /
columnar cells
overlying
fibrovascular core

Various images

Anaplastic choroid plexus papilloma

Oncocytic tumor

Positive stains
Negative stains
Differential diagnosis
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