CNS tumor
Diffuse astrocytic and oligodendroglial tumors
Diffuse astrocytoma IDH wildtype

Editorial Board Member: Maria Martinez-Lage, M.D.
Deputy Editor-in-Chief: Debra Zynger, M.D.
Eman Abdelzaher, M.D., Ph.D.

Topic Completed: 1 February 2018

Minor changes: 25 September 2020

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PubMed Search: Diffuse astrocytoma IDH-wildtype

Eman Abdelzaher, M.D., Ph.D.
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Table of Contents
Definition / general
Cite this page: Abdelzaher E. Diffuse astrocytoma IDH wildtype. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cnstumordiffuseastrocytomaIDHwild.html. Accessed September 30th, 2020.
Definition / general
  • Diffusely infiltrating astrocytoma negative for IDH mutations by immunohistochemistry (for mutant IDH1-R132H protein) and sequencing (for IDH1 codon 132 and IDH2 codon 172 gene mutations)
  • Most likely constitutes a variety of other entities with different clinical courses
  • Entities which have been found to be incorrectly diagnosed as diffuse astrocytoma IDH-wildtype include:
  • Diagnosis should be used with caution (Acta Neuropathol 2015;130:407)
  • Often lacks mutations in p53 and ATRX
  • Many IDH1 / 2 wildtype adult diffuse gliomas behave adversely, similar to glioblastoma (Acta Neuropathol 2015;130:407)
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