CNS tumor
Diffuse astrocytic and oligodendroglial tumors
Diffuse astrocytoma, NOS

Author: Eman Abdelzaher, M.D., Ph.D.

Revised: 5 April 2018, last major update February 2018

Copyright: (c) 2002-2018, PathologyOutlines.com, Inc.

PubMed Search: Diffuse astrocytoma NOS

Cite this page: Abdelzaher, E. Diffuse astrocytoma NOS. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cnstumordiffuseastrocytomaNOS.html. Accessed May 27th, 2018.
Definition / general
  • Tumor morphologically conforming with diffuse astrocytoma but in which IDH testing is not available or cannot be fully performed
  • Modifier "not otherwise specified" (NOS) does not refer to a specific entity; it simply indicates that the case requires additional molecular workup (Acta Neuropathol 2016;131:803)
  • Full IDH evaluation requires IDH sequencing for IDH1 codon 132 and IDH2 codon 172 mutations following a negative IDH1-R132H immunohistochemistry (Acta Neuropathol 2016;131:803)
Microscopic (histologic) images

Images hosted on PathOut server:

Images contributed by Eman Abdelzaher, M.D., Ph.D.

Diffuse astrocytoma, NOS: low power

Diffuse astrocytoma, NOS: medium power

Subpial accumulation

Diffuse astrocytoma, NOS: high power


Perineuronal satellitosis

Perivascular accumulation