Home   Chapter Home   Jobs   Conferences   Fellowships   Books



Advertisement

CNS tumor

Diffuse astrocytoma - fibrillary


Reviewers: Eman Abdelzaher, M.D., Ph.D. (see Reviewers page)
Revised: 29 February 2012, last major update February 2012
Copyright: (c) 2005-2012, PathologyOutlines.com, Inc.

Definition
=========================================================================

● The most frequent variant of diffuse astrocytoma

Micro description (Histopathology)
=========================================================================

● Fibrillary astrocytes with naked, atypical, elongated, irregular, hyperchromatic nuclei embedded in a fibrillary background
● Microcysts are common
● Some gemistocytes may be admixed

Micro images
=========================================================================



The processes of these star-shaped cells form a felt-like perivascular mantle


All astrocytomas have a tendency, as in this case, to appear microcystic


Well differentiated tumor is HAM56 negative (no macrophages)

Cytology images
=========================================================================



Smear shows neoplastic astrocytes with cytoplasmic glial processes and variable nuclear atypia

Positive stains
=========================================================================

● GFAP, PTAH

Differential diagnosis
=========================================================================

Gliosis: hypertrophy of cells rather than hyperplasia, even distribution
Oligodendroglioma grade II: uniformly rounded nuclei with small distinct nucleoli, perinuclear halos, chicken wire vessels, calcification, GFAP negative

End of CNS tumor > Diffuse astrocytoma - fibrillary


This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).