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CNS tumor

Diffuse astrocytoma - gemistocytic


Reviewers: Eman Abdelzaher, M.D., Ph.D. (see Reviewers page)
Revised: 29 February 2012, last major update February 2012
Copyright: (c) 2005-2012, PathologyOutlines.com, Inc.

Definition
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● Variant in which gemistocytes constitute > 20% of tumor cells

Case reports
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● Congenital brain tumor (University of Pittsburgh Case 368)

Gross images
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Frontal lobe tumor

Micro description (Histopathology)
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● Infiltrative tumor with gemistocytes, characterized by ample eosinophilic glassy cytoplasm and eccentric nuclei with frequent prominent nucleoli
● Background is coarse fibrillary; perivascular lymphocyte cuffing is common

Micro images
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Astrocytes with abundant eosinophilic cytoplasm


GFAP


Vimentin

Positive stains
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● GFAP, vimentin

Differential diagnosis
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Gliosis: hypertrophy of cells rather than hyperplasia, even distribution
Subependymal giant cell tumor: intraventricular, larger nuclei, non-infiltrative
Ganglioglioma: neoplastic neurons

End of CNS tumor > Diffuse astrocytoma - gemistocytic


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