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CNS tumor

Diffuse astrocytoma - protoplasmic

Reviewers: Eman Abdelzaher, M.D., Ph.D. (see Reviewers page)
Revised: 29 February 2012, last major update February 2012
Copyright: (c) 2005-2012, PathologyOutlines.com, Inc.


● Rare variant; often in temporal and frontal lobes (Am J Clin Pathol 1995;103:705)

Micro description (Histopathology)

● Composed predominantly of uniform cells with small cell bodies and flaccid processes
● Mucoid degeneration and microcysts are common

Micro images

Scant or vacuolated cytoplasm with short processes, vesicular nuclei and prominent nucleoli


Positive stains


Differential diagnosis

● In children, includes pilocytic astrocytoma and pilomyxoid astrocytoma (both are contrast enhancing), oligodendroglioma (1p deletion, Hum Pathol 2004;35:317)

End of CNS tumor > Diffuse astrocytoma - protoplasmic

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